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Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2

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产品编号 TMAB-11312

Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-SP1 (Thr739)。Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2 可用于 ICC/IF。

Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2

Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-11312

Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-SP1 (Thr739)。Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2 可用于 ICC/IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-SP1 (Thr739). Anti-Phospho-SP1 (Thr739) Polyclonal Antibody 2 can be used in ICC/IF.
Ig Type
IgG
交叉反应
Human (predicted:Cow,Horse,African Green Monkey)
应用ICC/IF
推荐剂量
ICC/IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
组织特异性Up-regulated in adenocarcinomas of the stomach (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Profound changes in patterns of gene expression can result from relatively small changes in the concentrations of sequence specific transcription factors. Synergistic interaction between factors bound to different sites within a transcriptional control region is supported by the work of Courey et al. (1989). Sp1 is a sequence specific transcription factor that recognizes GGGGCGGGGC and closely related sequences, which are often referred to as GC boxes. Sp1 binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. SP1 can interact with G/C rich motifs from serotonin receptor promoter. Kadonaga et al. (1987) cloned the human Sp1 cDNA and showed that it has contiguous zinc finger motifs and requires zinc for sequence specific binding to DNA. Altername：Sp1 transcription factor isoform a; TSFP1; TSFP 1; Specificity protein 1; Transcription factor Sp1.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human SP1 around the phosphorylation site of Thr739
抗原种属
Human
基因名称
SP1
基因ID
6667
蛋白名称
Transcription factor Sp1
Uniprot ID
P08047
功能
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.
化学信息
分子量Theoretical: 81 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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