购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11305

Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-SMC1 (Ser360)。Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody

Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11305

Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-SMC1 (Ser360)。Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SMC1 (Ser360). Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Chicken,Dog,Pig,Cow,Horse,Sheep,GuineaPig)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome. Chromosome, centromere, kinetochore. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesion complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesion complexes remain. At anaphase, the RAD21 subunit of the cohesion complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesion complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis
组织特异性The disease is caused by mutations affecting the gene represented in this entry. Disease description:A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes and can lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion complex associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human SMC1 around the phosphorylation site of Ser360
抗原种属
Human
基因名称
SMC1A
基因ID
27127
蛋白名称
Structural maintenance of chromosomes protein 1A
Uniprot ID
Q14683
功能
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesion complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
化学信息
分子量Theoretical: 136 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody | purchase Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody | Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody cost | order Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody | Anti-Phospho-SMC1 (Ser360) Polyclonal Antibody molecular weight