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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody

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货号 TMAB-11289

Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Smad1 (Ser463)。Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody

Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11289

Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Smad1 (Ser463)。Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Smad1 (Ser463). Anti-Phospho-Smad1 (Ser463) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Pig)
应用WBIHC-PIHC-FrIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.
组织特异性Ubiquitous. Highest expression seen in the heart and skeletal muscle.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human Smad1 around the phosphorylation site of Ser463
抗原种属
Human
基因名称
SMAD1
基因ID
4086
蛋白名称
Mothers against decapentaplegic homolog 1
Uniprot ID
Q15797
功能
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
化学信息
分子量Theoretical: 51 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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