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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody

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货号 TMAB-11286

Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-SLP76 (Tyr113)。Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody 可用于 WB。

Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody

Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-11286

Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-SLP76 (Tyr113)。Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SLP76 (Tyr113). Anti-Phospho-SLP76 (Tyr113) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Pig,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. Post-translational modifications : Phosphorylated after T-cell receptor activation by ZAP-70.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav’s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human SLP76 around the phosphorylation site of Tyr113
抗原种属
Human
基因名称
LCP2
基因ID
3937
蛋白名称
Lymphocyte cytosolic protein 2
Uniprot ID
Q13094
功能
Involved in T-cell antigen receptor mediated signaling.
化学信息
分子量Theoretical: 75 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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