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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2

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产品编号 TMAB-11266

Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-RUNX2 (Ser451)。Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2 可用于 FCM。

Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2

Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-11266

Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-RUNX2 (Ser451)。Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-RUNX2 (Ser451). Anti-Phospho-RUNX2 (Ser451) Polyclonal Antibody 2 can be used in FCM.
Ig Type
IgG
交叉反应
Human (predicted:Chicken,Dog,Pig,Cow,Horse)
应用FCM
推荐剂量
FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Specifically expressed in osteoblasts.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human RUNX2 around the phosphorylation site of Ser451
抗原种属
Human
基因名称
RUNX2
基因ID
860
蛋白名称
Runt-related transcription factor 2
Uniprot ID
Q13950
功能
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. [SUBUNIT] Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4.
化学信息
分子量Theoretical: 67 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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