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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody

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Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody
产品编号 TMAC-03613
别名 RIPK2 (p-Ser176), RIPK2 (p-S176), p-RIPK2 (Ser176), p-RIPK2 (S176)

Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RIPK2 (Ser176)。Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody

Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody
产品编号 TMAC-03613 别名 RIPK2 (p-Ser176), RIPK2 (p-S176), p-RIPK2 (Ser176), p-RIPK2 (S176)

Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RIPK2 (Ser176)。Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RIPK2 (Ser176). Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody can be used in WB,IHC.
别名RIPK2 (p-Ser176), RIPK2 (p-S176), p-RIPK2 (Ser176), p-RIPK2 (S176)
Ig Type
IgG
交叉反应
Human,Mouse
验证活性
1. Western blot analysis of extracts from 293 cells, treated with UV (15mins), using RIPK2 (Phospho-Ser176) antibody TMAC-03613. The lane on the right is treated with the synthesized peptide.
2. Immunohistochemistry analysis of paraffin-embedded human brain tissue using RIPK2 (Phospho-Ser176) antibody TMAC-03613. The picture on the right is treated with the synthesized peptide.
应用
WB
IHC
推荐剂量
WB: 1:500-3000; IHC: 1:50-100
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 176 (S-L-S(p)-Q-S) derived from Human RIPK2
抗原种属
human
Uniprot ID
O43353
化学信息
分子量Actual: 70 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

RIPK2 (pSer176)RIPK2 (pS176)RIPK2 (phospho-Ser176)RIPK2 (phospho-S176)pRIPK2 (Ser176)pRIPK2 (S176)

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