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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RELB (Ser552) Polyclonal Antibody

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Anti-Phospho-RELB (Ser552) Polyclonal Antibody
产品编号 TMAC-03569
别名 RELB (p-Ser552), RELB (p-S552), p-RELB (Ser552), p-RELB (S552)

Anti-Phospho-RELB (Ser552) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RELB (Ser552)。Anti-Phospho-RELB (Ser552) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。

Anti-Phospho-RELB (Ser552) Polyclonal Antibody

Anti-Phospho-RELB (Ser552) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-RELB (Ser552) Polyclonal Antibody
产品编号 TMAC-03569 别名 RELB (p-Ser552), RELB (p-S552), p-RELB (Ser552), p-RELB (S552)

Anti-Phospho-RELB (Ser552) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RELB (Ser552)。Anti-Phospho-RELB (Ser552) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,240
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RELB (Ser552) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RELB (Ser552). Anti-Phospho-RELB (Ser552) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
别名RELB (p-Ser552), RELB (p-S552), p-RELB (Ser552), p-RELB (S552)
Ig Type
IgG
交叉反应
Human,Mouse
应用
WB
IHC-P
IF(paraffin section)
ELISA
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:20000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
性状Liquid
缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
研究背景caution:Was originally (PubMed:1577270) thought to inhibit the transcriptional activity of nuclear factor NF-kappa-B.,domain:Both N- and C-terminal domains are required for transcriptional activation.,function:NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.,induction:By mitogens.,PTM:Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.,similarity:Contains 1 RHD (Rel-like) domain.,subunit:Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID.,
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human RelB around the phosphorylation site of Ser552. AA range:530-579
抗原种属
human
Uniprot ID
Q01201
化学信息
分子量Actual: 62 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

RELB (pSer552)RELB (pS552)RELB (phospho-Ser552)RELB (phospho-S552)pRELB (Ser552)pRELB (S552)

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