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Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody

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货号 TMAB-11232

Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Rb2 p130 (Ser952)。Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody 可用于 WB。

Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody

Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11232

Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Rb2 p130 (Ser952)。Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Rb2 p130 (Ser952). Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and is known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human Rb2 p130 around the phosphorylation site of Ser952
抗原种属
Human
基因名称
RBL2
基因ID
5934
蛋白名称
Retinoblastoma-like protein 2
Uniprot ID
Q08999
功能
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
化学信息
分子量Theoretical: 128 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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