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Anti-Phospho-RB1 (Ser807) Polyclonal Antibody
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产品编号 TMAC-03551
别名 RB1 (p-Ser807), RB1 (p-S807), p-RB1 (Ser807), p-RB1 (S807)
Anti-Phospho-RB1 (Ser807) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RB1 (Ser807)。Anti-Phospho-RB1 (Ser807) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-RB1 (Ser807) Polyclonal Antibody
Anti-Phospho-RB1 (Ser807) Polyclonal Antibody
还可以产品编号 TMAC-03551 别名 RB1 (p-Ser807), RB1 (p-S807), p-RB1 (Ser807), p-RB1 (S807)
Anti-Phospho-RB1 (Ser807) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RB1 (Ser807)。Anti-Phospho-RB1 (Ser807) Polyclonal Antibody 可用于 WB,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,245 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-RB1 (Ser807) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RB1 (Ser807). Anti-Phospho-RB1 (Ser807) Polyclonal Antibody can be used in WB,IHC. |
| 别名 | RB1 (p-Ser807), RB1 (p-S807), p-RB1 (Ser807), p-RB1 (S807) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extracts from 3T3 cells untreated or treated with UV using Rb (Phospho-Ser807) Antibody TMAC-03551. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Rb (Phospho-Ser807) Antibody TMAC-03551 (left) or the same antibody preincubated with blocking peptide (right). |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of serine 807 (Y-I-S(p)-P-L) derived from Human Rb |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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