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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody

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货号 TMAB-11222

Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RASA1 (Tyr460)。Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody

Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11222

Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RASA1 (Tyr460)。Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RASA1 (Tyr460). Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins (1,2). p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (3). Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations (3). Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold (4,5). The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity (6,7), and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human GAP around the phosphorylation site of Tyr460
抗原种属
Human
基因名称
RASA1
基因ID
5921
蛋白名称
Ras GTPase-activating protein 1
Uniprot ID
P20936
功能
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.
化学信息
分子量Theoretical: 116 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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