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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RARA (Ser77) Polyclonal Antibody

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Anti-Phospho-RARA (Ser77) Polyclonal Antibody
产品编号 TMAC-03585
别名 RARA (p-Ser77), RARA (p-S77), p-RARA (Ser77), p-RARA (S77)

Anti-Phospho-RARA (Ser77) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RARA (Ser77)。Anti-Phospho-RARA (Ser77) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-RARA (Ser77) Polyclonal Antibody

Anti-Phospho-RARA (Ser77) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-RARA (Ser77) Polyclonal Antibody
产品编号 TMAC-03585 别名 RARA (p-Ser77), RARA (p-S77), p-RARA (Ser77), p-RARA (S77)

Anti-Phospho-RARA (Ser77) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RARA (Ser77)。Anti-Phospho-RARA (Ser77) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,235
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RARA (Ser77) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RARA (Ser77). Anti-Phospho-RARA (Ser77) Polyclonal Antibody can be used in WB,IHC.
别名RARA (p-Ser77), RARA (p-S77), p-RARA (Ser77), p-RARA (S77)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from Jurkat cells treated with PMA (125ng/ml, 30mins), using Retinoic Acid Receptor α(Phospho-Ser77) antibody TMAC-03585. The lane on the right is treated with the synthesized peptide.
2. Western blot analysis of extracts from JK cells (Lane 2) and COS7 cells (Lane 3), using Retinoic Acid Receptor α (Phospho-Ser77) Antibody TMAC-03585. The lane on the left is treated with synthesized peptide.
3. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Retinoic Acid Receptor α (Phospho-Ser77) antibody TMAC-03585. The picture on the right is treated with the synthesized peptide.
应用
WB
IHC
推荐剂量
WB: 1:500-3000; IHC: 1:50-100
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function By similarity. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 77 (P-P-S(p)-P-P) derived from Human Retinoic Acid Receptor α
抗原种属
human
Uniprot ID
P10276
化学信息
分子量Actual: 45 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

RARA (pSer77)RARA (pS77)RARA (phospho-Ser77)RARA (phospho-S77)pRARA (Ser77)pRARA (S77)

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