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Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody

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Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody
产品编号 TMAC-03418
别名 Presenilin 1 (p-Ser357), Presenilin 1 (p-S357), p-Presenilin 1 (Ser357), p-Presenilin 1 (S357)

Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-Presenilin 1 (Ser357)。Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。

Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody

Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody
产品编号 TMAC-03418 别名 Presenilin 1 (p-Ser357), Presenilin 1 (p-S357), p-Presenilin 1 (Ser357), p-Presenilin 1 (S357)

Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-Presenilin 1 (Ser357)。Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,240
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Presenilin 1 (Ser357). Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
别名Presenilin 1 (p-Ser357), Presenilin 1 (p-S357), p-Presenilin 1 (Ser357), p-Presenilin 1 (S357)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
应用
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:5000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
性状Liquid
缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
研究背景presenilin 1(PSEN1) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008],
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human PSEN1 around the phosphorylation site of Ser357. AA range:323-372
抗原种属
human
Uniprot ID
化学信息
分子量Actual: 43 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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