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Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-Presenilin 1 (Ser357)。Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。
Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-Presenilin 1 (Ser357)。Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,480 | 5日内发货 | |
100 μL | ¥ 2,240 | 5日内发货 |
产品描述 | Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Presenilin 1 (Ser357). Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA. |
别名 | Presenilin 1 (p-Ser357), Presenilin 1 (p-S357), p-Presenilin 1 (Ser357), p-Presenilin 1 (S357) |
Ig Type | IgG |
交叉反应 | Human,Mouse,Rat |
应用 | |
推荐剂量 | WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:5000 |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
构建方式 | Polyclonal Antibody |
纯化方式 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
性状 | Liquid |
缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
研究背景 | presenilin 1(PSEN1) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008], |
偶联 | Unconjugated |
其他可选修饰符 | Phospho |
免疫原 | A synthesized phosphopeptide: human PSEN1 around the phosphorylation site of Ser357. AA range:323-372 |
抗原种属 | human |
Uniprot ID |
分子量 | Actual: 43 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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