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Anti-Phospho-PLB (Ser16) Polyclonal Antibody

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货号 TMAB-11165

Anti-Phospho-PLB (Ser16) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PLB (Ser16)。Anti-Phospho-PLB (Ser16) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-PLB (Ser16) Polyclonal Antibody

Anti-Phospho-PLB (Ser16) Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-11165

Anti-Phospho-PLB (Ser16) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PLB (Ser16)。Anti-Phospho-PLB (Ser16) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-PLB (Ser16) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PLB (Ser16). Anti-Phospho-PLB (Ser16) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum.
组织特异性Heart.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated phospho-protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser-10, Ser-16, Thr-17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human Cardiac phospholamban around the phosphorylation site of Ser16
抗原种属
Human
基因名称
PLN
基因ID
5350
蛋白名称
Cardiac phospholamban
Uniprot ID
P26678
功能
Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
化学信息
分子量Theoretical: 5.7 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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