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Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody

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货号 TMAB-11158

Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PKM2 (Tyr148)。Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody 可用于 FCM。

Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody

Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11158

Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PKM2 (Tyr148)。Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKM2 (Tyr148). Anti-Phospho-PKM2 (Tyr148) Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Pig,Cow,Rabbit,Sheep,GuineaPig)
应用FCM
推荐剂量
FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.
组织特异性Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human PKM2 around the phosphorylation site of Tyr148
抗原种属
Human
基因名称
PKM
基因ID
5315
蛋白名称
Pyruvate kinase PKM
Uniprot ID
P14618
功能
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
化学信息
分子量Theoretical: 58 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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