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Anti-Phospho-PIN1(Ser16) Polyclonal Antibody
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还可以产品编号 TMAB-11142
Anti-Phospho-PIN1(Ser16) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PIN1(Ser16)。Anti-Phospho-PIN1(Ser16) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。
Anti-Phospho-PIN1(Ser16) Polyclonal Antibody
Anti-Phospho-PIN1(Ser16) Polyclonal Antibody
一键复制产品信息 还可以产品编号 TMAB-11142
Anti-Phospho-PIN1(Ser16) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PIN1(Ser16)。Anti-Phospho-PIN1(Ser16) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,165 | 5日内发货 | |
| 100 μL | ¥ 1,975 | 5日内发货 | |
| 200 μL | ¥ 2,790 | 5日内发货 |
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| 产品描述 | Anti-Phospho-PIN1(Ser16) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PIN1(Ser16). Anti-Phospho-PIN1(Ser16) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Sheep) |
| 应用 | IHC-PIHC-FrIF |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Nucleus. Nucleus speckle. Cytoplasm. |
| 组织特异性 | The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration. |
| 免疫原 | KLH conjugated synthesised phosphopeptide: human Pin1 around the phosphorylation site of Ser16 |
| 抗原种属 | Human |
| 基因名称 | PIN1 |
| 基因ID | |
| 蛋白名称 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
| Uniprot ID | |
| 功能 | Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. |
| 分子量 | Theoretical: 18 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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