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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2

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货号 TMAB-11132

Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-PEA15 (Ser116)。Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2

Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-11132

Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-PEA15 (Ser116)。Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
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100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-PEA15 (Ser116). Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Cow,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Ubiquitously expressed.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景PED/PEA 15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15 kDa) is a widely expressed 15 kDa protein comprised of an N terminal region containing a canonical Death Effector Domain (DED) sequence and a nuclear export signal, and a C terminal region containing two serine phosphorylation sites. PED/PEA 15 has been implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin sensitive glucose transport in insulin responsive cells. Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116 (a substrate of CaMKII and Akt) is required for PED/PEA 15 function.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human PEA15 around the phosphorylation site of Ser116
抗原种属
Human
基因名称
PEA15
基因ID
8682
蛋白名称
Astrocytic phosphoprotein PEA-15
Uniprot ID
Q15121
功能
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
化学信息
分子量Theoretical: 15 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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