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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody

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货号 TMAB-11130

Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PDPK1 (Tyr373+Tyr376)。Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody 可用于 WB。

Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody

Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11130

Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PDPK1 (Tyr373+Tyr376)。Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

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产品描述
Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PDPK1 (Tyr373+Tyr376). Anti-Phospho-PDPK1 (Tyr373+Tyr376) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.
组织特异性Appears to be expressed ubiquitously.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human PDPK1 around the phosphorylation site of (Y373+Y376)
抗原种属
Human
基因名称
PDPK1
基因ID
5170
蛋白名称
3-phosphoinositide-dependent protein kinase 1
Uniprot ID
O15530
功能
Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.
化学信息
分子量Theoretical: 61 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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