Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605) is a Rabbit antibody targeting Phospho-PAK1/2/3 (Ser144/Ser141/Ser154). Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM.

IgG

1J605

Human,Mouse,Rat

WB: 1:500-5000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:100-200; IP: 1:20-50; FCM: 1:50-100

Monoclonal

A synthesized peptide: human PAK1 around the phosphorylation site of S144

Human

PAK1

Serine/threonine-protein kinase PAK 1

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2.