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顶部生物活性储存和溶解信息计算器

Anti-Phospho-p53 (Ser37) Polyclonal Antibody

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Anti-Phospho-p53 (Ser37) Polyclonal Antibody
产品编号 TMAC-02998
别名 p-p53 (Ser37), p-p53 (S37), p53 (p-Ser37), p53 (p-S37)

Anti-Phospho-p53 (Ser37) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-p53 (Ser37)。Anti-Phospho-p53 (Ser37) Polyclonal Antibody 可用于 WB,IHC,IF,ELISA。

Anti-Phospho-p53 (Ser37) Polyclonal Antibody

Anti-Phospho-p53 (Ser37) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-p53 (Ser37) Polyclonal Antibody
产品编号 TMAC-02998 别名 p-p53 (Ser37), p-p53 (S37), p53 (p-Ser37), p53 (p-S37)

Anti-Phospho-p53 (Ser37) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-p53 (Ser37)。Anti-Phospho-p53 (Ser37) Polyclonal Antibody 可用于 WB,IHC,IF,ELISA。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,240
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-p53 (Ser37) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser37). Anti-Phospho-p53 (Ser37) Polyclonal Antibody can be used in WB,IHC,IF,ELISA.
别名p-p53 (Ser37), p-p53 (S37), p53 (p-Ser37), p53 (p-S37)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Immunofluorescence staining of methanol-fixed Hela cells using p53 (Phospho-Ser37) Antibody TMAC-02998.
2. Western blot analysis of extracts from HT29 cells untreated or treated with UV, and MCF cells untreated or treated with Anisomycin using p53 (Phospho-Ser37) Antibody TMAC-02998.
应用
WB
IHC
IF
ELISA
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 37 (L-P-S(p)-Q-A) derived from Human p53
抗原种属
human
Uniprot ID
P04637
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pp53 (Ser37)pp53 (S37)p53 (pSer37)p53 (pS37)p53 (phospho-Ser37)p53 (phospho-S37)

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4个月前
5.0
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