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Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody
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产品编号 TMAC-02924
别名 p-OPRM1 (Ser375), p-OPRM1 (S375), OPRM1 (p-Ser375), OPRM1 (p-S375)
Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-OPRM1 (Ser375)。Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody 可用于 WB。
Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody
Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody
还可以产品编号 TMAC-02924 别名 p-OPRM1 (Ser375), p-OPRM1 (S375), OPRM1 (p-Ser375), OPRM1 (p-S375)
Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-OPRM1 (Ser375)。Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,240 | 5日内发货 |
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| 产品描述 | Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody is a Rabbit antibody targeting Phospho-OPRM1 (Ser375). Anti-Phospho-OPRM1 (Ser375) Polyclonal Antibody can be used in WB. |
| 别名 | p-OPRM1 (Ser375), p-OPRM1 (S375), OPRM1 (p-Ser375), OPRM1 (p-S375) |
| Ig Type | IgG |
| 交叉反应 | Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extracts from Rat brain tissue and Mouse brain tissue using Opioid Receptor (Phospho-Ser375) Antibody TMAC-02924. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of serine 375(H-P-S(p)-T-A) derived from Human Opioid Receptor |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 70-90 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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