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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody

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货号 TMAB-11060

Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-NMDAR2B (Tyr1252)。Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody

Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11060

Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-NMDAR2B (Tyr1252)。Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody is a Rabbit antibody targeting Phospho-NMDAR2B (Tyr1252). Anti-Phospho-NMDAR2B (Tyr1252) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat
应用IHC-PIHC-FrICC/IFIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
组织特异性Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human NMDAR2B around the phosphorylation site of Tyr1252
抗原种属
Human
基因名称
GRIN2B
基因ID
2904
蛋白名称
Glutamate receptor ionotropic, NMDA 2B
Uniprot ID
Q13224
功能
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
化学信息
分子量Theoretical: 164 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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