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Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2
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还可以产品编号 TMAB-11053
Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-NIPA (Ser354)。Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2 可用于 WB。
Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2
Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2
一键复制产品信息 还可以产品编号 TMAB-11053
Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-NIPA (Ser354)。Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,975 | 5日内发货 | |
| 200 μL | ¥ 2,790 | 5日内发货 |
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| 产品描述 | Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-NIPA (Ser354). Anti-Phospho-NIPA (Ser354) Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| 交叉反应 | Human (predicted:Mouse,Rat,Dog,Pig,Horse,Rabbit) |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Nuclear. |
| 组织特异性 | Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase. Nuclear cyclin B1 is a substrate of SCFNIPA. Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry. Thus, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle. |
| 免疫原 | KLH conjugated synthesised phosphopeptide: human NIPA around the phosphorylation site of Ser354 |
| 抗原种属 | Human |
| 基因名称 | ZC3HC1 |
| 基因ID | |
| 蛋白名称 | Nuclear-interacting partner of ALK |
| Uniprot ID | |
| 功能 | Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. |
| 分子量 | Theoretical: 55 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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