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Anti-Phospho-MLKL (Ser345) Polyclonal Antibody

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产品编号 TMAB-11000

Anti-Phospho-MLKL (Ser345) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MLKL (Ser345)。Anti-Phospho-MLKL (Ser345) Polyclonal Antibody 可用于 WB。

Anti-Phospho-MLKL (Ser345) Polyclonal Antibody

Anti-Phospho-MLKL (Ser345) Polyclonal Antibody

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Rating icon 还可以
产品编号 TMAB-11000

Anti-Phospho-MLKL (Ser345) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MLKL (Ser345)。Anti-Phospho-MLKL (Ser345) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,975
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200 μL
¥ 2,790
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产品介绍

生物活性
产品描述
Anti-Phospho-MLKL (Ser345) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MLKL (Ser345). Anti-Phospho-MLKL (Ser345) Polyclonal Antibody can be used in WB.
Ig Type
IgG
交叉反应
Human (predicted:Mouse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Lyophilized or Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: mouse MLKL around the phosphorylation site of Ser345
抗原种属
Mouse
基因名称
MLKL
基因ID
74568
蛋白名称
Mixed lineage kinase domain-like protein
Uniprot ID
Q9D2Y4
功能
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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