Anti-Phospho-MERTK/Mer (Tyr749, 753, 754) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MERTK/Mer (Tyr749, 753, 754). Anti-Phospho-MERTK/Mer (Tyr749, 753, 754) Polyclonal Antibody can be used in WB.

IgG

Human (predicted:Mouse,Rat)

Sample:
DU145 (Human) Cell Lysate at 30 μg
Primary: Anti-phospho-MERTK (Tyr749 + Tyr753 + Tyr754) (TMAB-01452) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 180 kDa
Observed band size: 180 kDa

WB: 1:500-2000

Polyclonal

KLH conjugated synthesised phosphopeptide: human MERTK around the phosphorylation site of Tyr749 + Tyr753 + Tyr754

Human

MERTK

Tyrosine-protein kinase Mer

Kinases,Visual system,Receptor Tyrosine Kinases

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.