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Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3

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产品编号 TMAB-10968

Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 Phospho-MDMX (Ser367)。Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3

Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10968

Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 Phospho-MDMX (Ser367)。Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
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100 μL
¥ 1,970
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200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-MDMX (Ser367). Anti-Phospho-MDMX (Ser367) Polyclonal Antibody 3 can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Mouse (predicted:Human,Rat,Dog,Pig,Horse,Rabbit)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Expressed in all tissues tested with high levels in thymus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human MDMX Receptor around the phosphorylation site of Ser367
抗原种属
Human
基因名称
MDM4
基因ID
4194
蛋白名称
Protein Mdm4
Uniprot ID
O15151
功能
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
化学信息
分子量Theoretical: 55 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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