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顶部生物活性储存和溶解信息计算器

Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody

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Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody
产品编号 TMAC-02507
别名 p-MDM2 (Ser186, 188), p-MDM2 (S186, 188), MDM2 (p-Ser186, 188), MDM2 (p-S186, 188)

Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MDM2 (Ser186, 188)。Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody 可用于 IF。

Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody

Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody
产品编号 TMAC-02507 别名 p-MDM2 (Ser186, 188), p-MDM2 (S186, 188), MDM2 (p-Ser186, 188), MDM2 (p-S186, 188)

Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MDM2 (Ser186, 188)。Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody 可用于 IF。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MDM2 (Ser186, 188). Anti-Phospho-MDM2 (Ser186, 188) Polyclonal Antibody can be used in IF.
别名p-MDM2 (Ser186, 188), p-MDM2 (S186, 188), MDM2 (p-Ser186, 188), MDM2 (p-S186, 188)
Ig Type
IgG
交叉反应
Human
验证活性
1. Immunofluorescence staining of methanol-fixed HeLa cells using MDM2 (Phospho-Ser186/Ser188) Antibody TMAC-02507.
应用
IF
推荐剂量
IF: 1:100-200
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of Ser186/Ser188(H-K-S(p)-D-S(p)-I-S) derived from Human MDM2
抗原种属
human
Uniprot ID
Q00987
化学信息
分子量Actual: 55 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

pMDM2 (Ser186, 188)pMDM2 (S186, 188)MDM2 (pSer186, 188)MDM2 (pS186, 188)MDM2 (phospho-Ser186, 188)MDM2 (phospho-S186, 188)

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