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顶部生物活性储存和溶解信息计算器

Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody

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Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody
产品编号 TMAC-02510
别名 p-MDM2 (Ser166), p-MDM2 (S166), MDM2 (p-Ser166), MDM2 (p-S166)

Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MDM2 (Ser166)。Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody 可用于 WB,IHC,IF。

Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody

Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody
产品编号 TMAC-02510 别名 p-MDM2 (Ser166), p-MDM2 (S166), MDM2 (p-Ser166), MDM2 (p-S166)

Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MDM2 (Ser166)。Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody 可用于 WB,IHC,IF。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,235
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MDM2 (Ser166). Anti-Phospho-MDM2 (Ser166) Polyclonal Antibody can be used in WB,IHC,IF.
别名p-MDM2 (Ser166), p-MDM2 (S166), MDM2 (p-Ser166), MDM2 (p-S166)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from 293 cells untreated or treated with Hydroxyurea using MDM2 (phospho-Ser166) Antibody TMAC-02510.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MDM2 (Phospho-Ser166) Antibody TMAC-02510 (left) or the same antibody preincubated with blocking peptide (right).
3. Immunofluorescence staining of methanol-fixed Hela cells using MDM2 (phospho-Ser166) Antibody TMAC-02510.
应用
WB
IHC
IF
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of Serine 166 (A-I-S(p)-E-T) derived from Human MDM2
抗原种属
human
Uniprot ID
Q00987
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pMDM2 (Ser166)pMDM2 (S166)MDM2 (pSer166)MDM2 (pS166)MDM2 (phospho-Ser166)MDM2 (phospho-S166)

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