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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-MDM2 (Ser166) Antibody (4W956)

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货号 TMAB-10964

Anti-Phospho-MDM2 (Ser166) Antibody (4W956) 是一种 Rabbit 抗体，靶向 Phospho-MDM2 (Ser166)。Anti-Phospho-MDM2 (Ser166) Antibody (4W956) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-MDM2 (Ser166) Antibody (4W956)

Anti-Phospho-MDM2 (Ser166) Antibody (4W956)

一键复制产品信息
Rating icon 还可以
货号 TMAB-10964

Anti-Phospho-MDM2 (Ser166) Antibody (4W956) 是一种 Rabbit 抗体，靶向 Phospho-MDM2 (Ser166)。Anti-Phospho-MDM2 (Ser166) Antibody (4W956) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MDM2 (Ser166) Antibody (4W956) is a Rabbit antibody targeting Phospho-MDM2 (Ser166). Anti-Phospho-MDM2 (Ser166) Antibody (4W956) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
4W956
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
组织特异性Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome.
抗原信息
免疫原
A synthesized peptide: human MDM2 around the phosphorylation site of S166
抗原种属
Human
基因名称
MDM2
基因ID
4193
蛋白名称
E3 ubiquitin-protein ligase Mdm2
Uniprot ID
Q00987
功能
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.
化学信息
分子量Theoretical: 55 kDa. Actual: 100 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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