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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody

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货号 TMAB-10962

Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MDC1 (Thr4)。Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody 可用于 WB。

Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody

Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10962

Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MDC1 (Thr4)。Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MDC1 (Thr4). Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Note=Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AFX. Colocalizes with APTX at sites of DNA double-strand breaks.
组织特异性Highly expressed in testis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq].
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human MCSF Receptor around the phosphorylation site of Thr4
抗原种属
Human
基因名称
MDC1
基因ID
9656
蛋白名称
Mediator of DNA damage checkpoint protein 1
Uniprot ID
Q14676
功能
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
化学信息
分子量Theoretical: 227 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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