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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody

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货号 TMAB-10955

Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MCAM (Tyr641)。Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody 可用于 WB。

Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody

Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10955

Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MCAM (Tyr641)。Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MCAM (Tyr641). Anti-Phospho-MCAM (Tyr641) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse,Rat
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein.
组织特异性Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景MCAM (MUC18 antigen, CD146), a member of the immuoglobulin superfamily, is an intrinsic membrane glycoprotein of 110-120 kDa found on the surface of endothelial cells, bone marrow fibroblasts and various melanomas. MCAM (Melanoma adhesion molecule) has been used as a marker of tumor progression in human melanoma because expression in those tumors correlates strongly with poor prognosis and the development of metastic disease. In addition, a number of human T, B and myeloid leukemic cell lines seem to express MCAM. The close structural relationship with N-CAM and related molecules suggests that MCAM may be also a developmentally regulated cell adhesion.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human MCAM around the phosphorylation site of Tyr641
抗原种属
Human
基因名称
MCAM
基因ID
4162
蛋白名称
Cell surface glycoprotein MUC18
Uniprot ID
P43121
功能
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
化学信息
分子量Theoretical: 71 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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