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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody

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货号 TMAB-10918

Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-LRP6 (Ser1490)。Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody

Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10918

Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-LRP6 (Ser1490)。Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LRP6 (Ser1490). Anti-Phospho-LRP6 (Ser1490) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Chicken,Dog,Pig,Cow,Horse)
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD.
组织特异性Widely co-expressed with LRP5 during embryogenesis and in adult tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human LRP6 around the phosphorylation site of Ser1490
抗原种属
Human
基因名称
LRP6
基因ID
4040
蛋白名称
Low-density lipoprotein receptor-related protein 6
Uniprot ID
O75581
功能
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
化学信息
分子量Theoretical: 175 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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