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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody

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货号 TMAB-10917

Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-LRP5 (Thr1492)。Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody

Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10917

Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-LRP5 (Thr1492)。Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LRP5 (Thr1492). Anti-Phospho-LRP5 (Thr1492) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein. Endoplasmic reticulum (By similarity). Note=Chaperoned to the plasma membrane by MESD (By similarity).
组织特异性Widely expressed, with the highest level of expression in the liver and in aorta.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景LRP5 is involved in the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Defects in LRP5 are a cause of autosomal dominant and autosomal recessive familial exudative vitreoretinopathy (FEVR). Autosomal dominant FEVR is also referred to as exudative vitreoretinopathy 1 (EVR1); also known as Criswick-Schepens syndrome. FEVR is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. FEVR is reported to have a penetrance of 100%, but clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human LRP5 around the phosphorylation site of Thr1492
抗原种属
Human
基因名称
LRP5
基因ID
4041
蛋白名称
Low-density lipoprotein receptor-related protein 5
Uniprot ID
O75197
功能
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
化学信息
分子量Theoretical: 176 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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