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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody

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货号 TMAB-10916

Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-LRP1 (Ser4523)。Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody

Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10916

Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-LRP1 (Ser4523)。Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LRP1 (Ser4523). Anti-Phospho-LRP1 (Ser4523) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse)
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Membrane, coated pit and Cytoplasm. Nucleus. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
组织特异性Most abundant in liver, brain and lung.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human LRP1 around the phosphorylation site of Ser4523
抗原种属
Human
基因名称
LRP1
基因ID
4035
蛋白名称
Prolow-density lipoprotein receptor-related protein 1
Uniprot ID
Q07954
功能
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
化学信息
分子量Theoretical: 85/515 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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