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顶部生物活性储存和溶解信息计算器

Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody

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Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody
产品编号 TMAC-02187
别名 p-ITGB1 (Thr789), p-ITGB1 (T789), ITGB1 (p-Thr789), ITGB1 (p-T789)

Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ITGB1 (Thr789)。Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody

Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody
产品编号 TMAC-02187 别名 p-ITGB1 (Thr789), p-ITGB1 (T789), ITGB1 (p-Thr789), ITGB1 (p-T789)

Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ITGB1 (Thr789)。Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,230
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ITGB1 (Thr789). Anti-Phospho-ITGB1 (Thr789) Polyclonal Antibody can be used in WB,IHC.
别名p-ITGB1 (Thr789), p-ITGB1 (T789), ITGB1 (p-Thr789), ITGB1 (p-T789)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from HepG2 cells treated with Ca2+ using Integrin β1 (Phospho-Thr789) Antibody TMAC-02187. The lane on the right is treated with the antigen-specific peptide.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Integrin β1 (Phospho-Thr789) antibody TMAC-02187 (left) or the same antibody preincubated with blocking peptide (right).
应用
WB
IHC
推荐剂量
WB: 1:500-1000; IHC: 1:50-100
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of threonine 789(V-E-T(p)-V-V) derived from Human Integrin β1
抗原种属
human
Uniprot ID
P05556
化学信息
分子量Actual: 90 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

pITGB1 (Thr789)pITGB1 (T789)ITGB1 (pThr789)ITGB1 (pT789)ITGB1 (phospho-Thr789)ITGB1 (phospho-T789)

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4个月前
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