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Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody
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还可以产品编号 TMAB-10879
Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IRS1 (Ser636+Ser639)。Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF,FCM。
Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody
Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody
一键复制产品信息 还可以产品编号 TMAB-10879
Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IRS1 (Ser636+Ser639)。Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,175 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,780 | 5日内发货 |
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| 产品描述 | Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRS1 (Ser636+Ser639). Anti-Phospho-IRS1 (Ser636+Ser639) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM. |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Rabbit) |
| 应用 | IHC-PIHC-FrICC/IFIFFCM |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | IRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli. |
| 组织特异性 | Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed. |
| 免疫原 | KLH conjugated synthesised phosphopeptide: human IRS1 around the phosphorylation site of Ser636/639 |
| 抗原种属 | Human |
| 基因名称 | IRS1 |
| 基因ID | |
| 蛋白名称 | Insulin receptor substrate 1 |
| Uniprot ID | |
| 功能 | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. |
| 分子量 | Theoretical: 132 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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