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Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody
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产品编号 TMAC-02217
别名 p-IRF3 (Ser385), p-IRF3 (S385), IRF3 (p-Ser385), IRF3 (p-S385)
Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IRF3 (Ser385)。Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody 可用于 WB。
Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody
Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody
还可以产品编号 TMAC-02217 别名 p-IRF3 (Ser385), p-IRF3 (S385), IRF3 (p-Ser385), IRF3 (p-S385)
Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IRF3 (Ser385)。Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,235 | 5日内发货 |
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抗原信息
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| 产品描述 | Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRF3 (Ser385). Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody can be used in WB. |
| 别名 | p-IRF3 (Ser385), p-IRF3 (S385), IRF3 (p-Ser385), IRF3 (p-S385) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse |
| 验证活性 | 1. Western blot analysis of extracts from Mouse heart tissue using IRF-3 (Phospho-Ser385) Antibody TMAC-02217. The lane on the right is treated with the antigen-specific peptide. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of Serine 385 (G-A-S(p)-S-L) derived from Human EGFR |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 57 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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