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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody

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货号 TMAB-10859

Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ILK-1 (Ser259)。Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody 可用于 WB。

Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody

Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10859

Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ILK-1 (Ser259)。Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ILK-1 (Ser259). Anti-Phospho-ILK-1 (Ser259) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
组织特异性Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells; its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human ILK-1 around the phosphorylation site of Ser259
抗原种属
Human
基因名称
ILK
基因ID
3611
蛋白名称
Integrin-linked protein kinase
Uniprot ID
Q13418
功能
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
化学信息
分子量Theoretical: 50 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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