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Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody
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还可以产品编号 TMAB-10858
Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ILK-1 (Ser246)。Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。
Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody
Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody
一键复制产品信息 还可以产品编号 TMAB-10858
Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ILK-1 (Ser246)。Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,975 | 5日内发货 | |
| 200 μL | ¥ 2,790 | 5日内发货 |
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| 产品描述 | Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ILK-1 (Ser246). Anti-Phospho-ILK-1 (Ser246) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| 交叉反应 | Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| 应用 | WBIHC-PIHC-FrIF |
| 推荐剂量 | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| 组织特异性 | Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells; its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active. |
| 免疫原 | KLH conjugated Synthesised phosphopeptide: human ILK-1 around the phosphorylation site of Ser246 |
| 抗原种属 | Human |
| 基因名称 | ILK |
| 基因ID | |
| 蛋白名称 | Integrin-linked protein kinase |
| Uniprot ID | |
| 功能 | Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. |
| 分子量 | Theoretical: 50 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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