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Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody
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产品编号 TMAC-02123
别名 p-IKK- alpha (Thr23), p-IKK- alpha (T23), IKK- alpha (p-Thr23), IKK- alpha (p-T23)
Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IKK- alpha (Thr23)。Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody
Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody
还可以产品编号 TMAC-02123 别名 p-IKK- alpha (Thr23), p-IKK- alpha (T23), IKK- alpha (p-Thr23), IKK- alpha (p-T23)
Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IKK- alpha (Thr23)。Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody 可用于 WB,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,245 | 5日内发货 |
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| 产品描述 | Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IKK- alpha (Thr23). Anti-Phospho-IKK- alpha (Thr23) Polyclonal Antibody can be used in WB,IHC. |
| 别名 | p-IKK- alpha (Thr23), p-IKK- alpha (T23), IKK- alpha (p-Thr23), IKK- alpha (p-T23) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extracts from 293 cells untreated or treated with TNF using IKK a (Phospho-Thr23) Antibody TMAC-02123. 2. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using IKK a (Phospho-Thr23) Antibody TMAC-02123 (left) or the same antibody preincubated with blocking peptide (right). 3. Western blot analysis of extracts from Hela cells, treated with EGF or calf intestinal phosphatase (CIP), using IKK α (Phospho-Thr23) Antibody TMAC-02123. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of threonine 23 (L-G-T(p)-G-G) derived from Human IKK a |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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