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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody

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货号 TMAB-10840

Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IKB epsilon (Ser22)。Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody

Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10840

Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IKB epsilon (Ser22)。Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IKB epsilon (Ser22). Anti-Phospho-IKB epsilon (Ser22) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Cow,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human IKB epsilon around the phosphorylation site of Ser22
抗原种属
Human
基因名称
NFKBIE
基因ID
4794
蛋白名称
NF-kappa-B inhibitor epsilon
Uniprot ID
O00221
功能
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
化学信息
分子量Theoretical: 39 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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