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Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2

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货号 TMAB-10817

Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-HSF1 (Ser307)。Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2 可用于 WB。

Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2

Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-10817

Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-HSF1 (Ser307)。Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-HSF1 (Ser307). Anti-Phospho-HSF1 (Ser307) Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Cytoplasmic duringnormal growth. On activation, translocates to nuclear stressgranules. Colocalizes with SUMO1 in nuclear stress granules.
组织特异性Phosphorylated on multiple serine residues, a subset of whichare involved in stress-related regulation of transcriptionactivation. Constitutive phosphorylation represses transcriptionalactivity at normal temperatures. Levels increase on specificresidues heat-shock and enhance HSF1 transactivation activity.Phosphorylation on Ser-307 derepresses activation on heat-stressand in combination with Ser-303 phosphorylation appears to beinvolved in recovery after heat-stress. Phosphorylated on Ser-230by CAMK2, in vitro. Cadmium also enhances phosphorylation at thissite. Phosphorylation on Ser-303 is a prerequisite for HSF1sumoylation. Phosphorylation on Ser-121 inhibits transactivationand promotes HSP90 binding. Phosphorylation on Thr-142 alsomediates transcriptional activity induced by heat.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human HSF1 around the phosphorylation site of Ser307
抗原种属
Human
基因名称
HSF1
基因ID
3297
蛋白名称
Heat shock factor protein 1
Uniprot ID
Q00613
功能
DNA-binding protein that specifically binds heat shockpromoter elements (HSE) and activates transcription. In highereukaryotes, HSF is unable to bind to the HSE unless the cells areheat shocked.
化学信息
分子量Theoretical: 57 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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