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Anti-Phospho-HNRNPK (Ser216) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-HNRNPK (Ser216)。Anti-Phospho-HNRNPK (Ser216) Polyclonal Antibody 可用于 WB。
Anti-Phospho-HNRNPK (Ser216) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-HNRNPK (Ser216)。Anti-Phospho-HNRNPK (Ser216) Polyclonal Antibody 可用于 WB。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,480 | 5日内发货 | |
100 μL | ¥ 2,230 | 5日内发货 |
产品描述 | Anti-Phospho-HNRNPK (Ser216) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HNRNPK (Ser216). Anti-Phospho-HNRNPK (Ser216) Polyclonal Antibody can be used in WB. |
别名 | p-HNRNPK (Ser216), p-HNRNPK (S216), HNRNPK (p-Ser216), HNRNPK (p-S216) |
Ig Type | IgG |
交叉反应 | Human,Mouse,Rat |
验证活性 | 1. Western blot analysis of extracts from JurKat cells, using hnRNP K (Phospho-Ser216) antibody TMAC-01995. The lane on the right is treated with the synthesized peptide. |
应用 | |
推荐剂量 | WB: 1:500-3000 |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
构建方式 | Polyclonal Antibody |
纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
性状 | Liquid |
缓冲液 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
研究背景 | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction By similarity. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. |
偶联 | Unconjugated |
其他可选修饰符 | Phospho |
免疫原 | Peptide sequence around phosphorylation site of serine 216 (S-E-S(p)-P-I) derived from Human hnRNP K |
抗原种属 | human |
Uniprot ID |
分子量 | Actual: 55 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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