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Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 2

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Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 2
产品编号 TMAC-01852
别名 p-H2AFX (Ser139), p-H2AFX (S139), H2AFX (p-Ser139), H2AFX (p-S139)

Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-H2AFX (Ser139)。Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 可用于 WB,IF。

Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 2

Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 2

Rating icon 还可以
Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 2
产品编号 TMAC-01852 别名 p-H2AFX (Ser139), p-H2AFX (S139), H2AFX (p-Ser139), H2AFX (p-S139)

Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-H2AFX (Ser139)。Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody 可用于 WB,IF。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,240
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody is a Rabbit antibody targeting Phospho-H2AFX (Ser139). Anti-Phospho-H2AFX (Ser139) Polyclonal Antibody can be used in WB,IF.
别名p-H2AFX (Ser139), p-H2AFX (S139), H2AFX (p-Ser139), H2AFX (p-S139)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from HT29 cells untreated (lane 1) or treated with UV (lane 2) using Histone H2A.X (Phospho-Ser139) Antibody TMAC-01852.
2. Immunofluorescence staining of methanol-fixed Hela cells using Histone H2A.X (Phospho-Ser139) Antibody TMAC-01852.
3. Western blot analysis of extracts from 293 cells, treated with UV+serum or calf intestinal phosphatase (CIP), using Histone H2A.X (Phospho-Ser139) Antibody TMAC-01852.
应用
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 139 (Q-A-S(p)-Q-E) derived from Human Histone H2AX
抗原种属
human
Uniprot ID
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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