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Anti-Phospho-GSK3B (Ser 9) Antibody (9V640)
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产品编号 TMAC-03220
别名 p-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9)
Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) 是一种 Rabbit 抗体，靶向 Phospho-GSK3B (Ser 9)。Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) 可用于 WB,ICC/IF,IHC。
Anti-Phospho-GSK3B (Ser 9) Antibody (9V640)
Anti-Phospho-GSK3B (Ser 9) Antibody (9V640)
还可以产品编号 TMAC-03220 别名 p-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9)
Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) 是一种 Rabbit 抗体，靶向 Phospho-GSK3B (Ser 9)。Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) 可用于 WB,ICC/IF,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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| 产品描述 | Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) is a Rabbit antibody targeting Phospho-GSK3B (Ser 9). Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) can be used in WB,ICC/IF,IHC. |
| 别名 | p-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9) |
| Ig Type | IgG |
| 克隆号 | 9V640 |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of Phospho-GSK3 beta (Ser 9) on different lysates using anti-Phospho-GSK3 beta (Ser 9) antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: MCF-7. 2. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin. 6. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin. 7. ICC staining Phospho-GSK3 beta (Ser 9) in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. ICC staining Phospho-GSK3 beta (Ser 9) in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Glycogen synthase kinase-3α (GSK-3α) and GSK-3β are highly similar isoforms of serine/ threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3β activity is also required for nuclear activity of Rel dimers, which mediate an apoptotic response to TNFα in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3α and GSK-3β induces phosphorylation of Ser 21 and Ser 9, respectively, through a phosphatidylinositol 3-kinase (PI 3-K)-protein kinase B (PKB)-dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3α or Ser 9 of GSK-3β and inactivates both forms. GSK-3α/β is positively regulated by phosphorylation on Tyr 279 and Tyr 216, respectively. Activated GSK-3α/β participates in energy metabolism, neuronal cell development, and body pattern formation. Tyrosine dephosphorylation of GSK-3 is involved in its extracellular signal-dependent inactivation. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | A synthesized phosphopeptide: human GSK3 beta around the phosphorylation site of Ser9 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 47 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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