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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-GSK3B (Ser 9) Antibody (9V640)

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货号 TMAC-03220

别名 p-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9)

Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) 是一种 Rabbit 抗体，靶向 Phospho-GSK3B (Ser 9)。Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) 可用于 ICC/IF,IHC,WB。

Anti-Phospho-GSK3B (Ser 9) Antibody (9V640)

Anti-Phospho-GSK3B (Ser 9) Antibody (9V640)

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货号 TMAC-03220 别名 p-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9)

Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) 是一种 Rabbit 抗体，靶向 Phospho-GSK3B (Ser 9)。Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) 可用于 ICC/IF,IHC,WB。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) is a Rabbit antibody targeting Phospho-GSK3B (Ser 9). Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) can be used in ICC/IF,IHC,WB.
别名p-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9)
Ig Type
IgG
克隆号
9V640
反应种属
Human
验证活性
1. Western blot analysis of Phospho-GSK3 beta (Ser 9) on different lysates using anti-Phospho-GSK3 beta (Ser 9) antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: MCF-7.
2. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin.
6. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Phospho-GSK3 beta (Ser 9) antibody. Counter stained with hematoxylin.
7. ICC staining Phospho-GSK3 beta (Ser 9) in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
8. ICC staining Phospho-GSK3 beta (Ser 9) in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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应用ICC/IFIHCWB
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Glycogen synthase kinase-3α (GSK-3α) and GSK-3β are highly similar isoforms of serine/ threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3β activity is also required for nuclear activity of Rel dimers, which mediate an apoptotic response to TNFα in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3α and GSK-3β induces phosphorylation of Ser 21 and Ser 9, respectively, through a phosphatidylinositol 3-kinase (PI 3-K)-protein kinase B (PKB)-dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3α or Ser 9 of GSK-3β and inactivates both forms. GSK-3α/β is positively regulated by phosphorylation on Tyr 279 and Tyr 216, respectively. Activated GSK-3α/β participates in energy metabolism, neuronal cell development, and body pattern formation. Tyrosine dephosphorylation of GSK-3 is involved in its extracellular signal-dependent inactivation.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human GSK3 beta around the phosphorylation site of Ser9
抗原种属
human
Uniprot ID
P49841
化学信息
分子量Theoretical: 47 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器

关键词

pGSK3B (Ser 9)pGSK3B (S 9)GSK3B (pSer 9)GSK3B (pS 9)GSK3B (phospho-Ser 9)GSK3B (phospho-S 9)
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