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顶部生物活性储存和溶解信息计算器

Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2

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产品编号 TMAB-10736

Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Girdin (Ser1417)。Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2 可用于 WB,FCM。

Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2

Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10736

Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Girdin (Ser1417)。Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,160
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100 μL
¥ 1,965
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200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Girdin (Ser1417). Anti-Phospho-Girdin (Ser1417) Polyclonal Antibody 2 can be used in WB,FCM.
Ig Type
IgG
交叉反应
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides.
组织特异性Expressed ubiquitously.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human APE around the phosphorylation site of Ser1417
抗原种属
Human
基因名称
CCDC88A
基因ID
55704
蛋白名称
Girdin
Uniprot ID
Q3V6T2
功能
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
化学信息
分子量Theoretical: 206 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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