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Anti-Phospho-GAB2 (Ser623) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-GAB2 (Ser623)。Anti-Phospho-GAB2 (Ser623) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-GAB2 (Ser623) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-GAB2 (Ser623)。Anti-Phospho-GAB2 (Ser623) Polyclonal Antibody 可用于 WB,IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,485 | 5日内发货 | |
100 μL | ¥ 2,235 | 5日内发货 |
产品描述 | Anti-Phospho-GAB2 (Ser623) Polyclonal Antibody is a Rabbit antibody targeting Phospho-GAB2 (Ser623). Anti-Phospho-GAB2 (Ser623) Polyclonal Antibody can be used in WB,IHC. |
别名 | p-GAB2 (Ser623), p-GAB2 (S623), GAB2 (p-Ser623), GAB2 (p-S623) |
Ig Type | IgG |
交叉反应 | Human,Mouse |
验证活性 | 1. Western blot analysis of extracts from 293 cells (Lane 2), HeLa cells (Lane 3) and HepG2 cells (Lane 4), using Gab2 (Phospho-Ser623) Antibody TMAC-01585. The lane on the left is treated with antigen-specific peptide. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Gab2 (Phospho-Ser623) antibody TMAC-01585 (left) or the same antibody preincubated with blocking peptide (right). |
应用 | |
推荐剂量 | WB: 1:500-1000; IHC: 1:50-100 |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
构建方式 | Polyclonal Antibody |
纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
性状 | Liquid |
缓冲液 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
研究背景 | This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. |
偶联 | Unconjugated |
其他可选修饰符 | Phospho |
免疫原 | Peptide sequence around phosphorylation site of Serine 623(P-S-S(p)-P-S) derived from Human Gab2 |
抗原种属 | human |
Uniprot ID |
分子量 | Actual: 80 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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