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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-FYN (Tyr530) Polyclonal Antibody

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货号 TMAC-01577

别名 p-FYN (Y530), p-FYN (Tyr530), FYN (p-Y530), FYN (p-Tyr530)

Anti-Phospho-FYN (Tyr530) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-FYN (Tyr530)。Anti-Phospho-FYN (Tyr530) Polyclonal Antibody 可用于 IF,IHC,WB。

Anti-Phospho-FYN (Tyr530) Polyclonal Antibody

Anti-Phospho-FYN (Tyr530) Polyclonal Antibody

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货号 TMAC-01577 别名 p-FYN (Y530), p-FYN (Tyr530), FYN (p-Y530), FYN (p-Tyr530)

Anti-Phospho-FYN (Tyr530) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-FYN (Tyr530)。Anti-Phospho-FYN (Tyr530) Polyclonal Antibody 可用于 IF,IHC,WB。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-FYN (Tyr530) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FYN (Tyr530). Anti-Phospho-FYN (Tyr530) Polyclonal Antibody can be used in IF,IHC,WB.
别名p-FYN (Y530), p-FYN (Tyr530), FYN (p-Y530), FYN (p-Tyr530)
Ig Type
IgG
反应种属
Human,Mouse,Rat,Bovine,Pig,zebrafish
验证活性
1. Western blot analysis of extracts from Mouse brain tissue using Fyn (Phospho-Tyr530) Antibody TMAC-01577. The lane on the left is treated with the antigen-specific peptide.
verifiedActivity
应用IFIHCWB
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of Tyrosine 530 (P-Q-Y(p)-Q-P) derived from Human Fyn
抗原种属
human
Uniprot ID
P06241
化学信息
分子量Actual: 59 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器

关键词

pFYN (Y530)pFYN (Tyr530)FYN (pY530)FYN (pTyr530)FYN (phospho-Y530)FYN (phospho-Tyr530)
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