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Anti-Phospho-FYN (Tyr530) Polyclonal Antibody
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产品编号 TMAC-01577
别名 p-FYN (Y530), p-FYN (Tyr530), FYN (p-Y530), FYN (p-Tyr530)
Anti-Phospho-FYN (Tyr530) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-FYN (Tyr530)。Anti-Phospho-FYN (Tyr530) Polyclonal Antibody 可用于 WB,IHC,IF。
Anti-Phospho-FYN (Tyr530) Polyclonal Antibody
Anti-Phospho-FYN (Tyr530) Polyclonal Antibody
还可以产品编号 TMAC-01577 别名 p-FYN (Y530), p-FYN (Tyr530), FYN (p-Y530), FYN (p-Tyr530)
Anti-Phospho-FYN (Tyr530) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-FYN (Tyr530)。Anti-Phospho-FYN (Tyr530) Polyclonal Antibody 可用于 WB,IHC,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,245 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
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| 产品描述 | Anti-Phospho-FYN (Tyr530) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FYN (Tyr530). Anti-Phospho-FYN (Tyr530) Polyclonal Antibody can be used in WB,IHC,IF. |
| 别名 | p-FYN (Y530), p-FYN (Tyr530), FYN (p-Y530), FYN (p-Tyr530) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat,Bovine,Pig,zebrafish |
| 验证活性 | 1. Western blot analysis of extracts from Mouse brain tissue using Fyn (Phospho-Tyr530) Antibody TMAC-01577. The lane on the left is treated with the antigen-specific peptide. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of Tyrosine 530 (P-Q-Y(p)-Q-P) derived from Human Fyn |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 59 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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