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顶部生物活性储存和溶解信息计算器

Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2

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产品编号 TMAB-10707

Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-FLT3 (Tyr599)。Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2 可用于 WB。

Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2

Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10707

Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-FLT3 (Tyr599)。Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-FLT3 (Tyr599). Anti-Phospho-FLT3 (Tyr599) Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
交叉反应
Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen.
组织特异性Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景CD135 is a tyrosine kinase receptor expressed on normal cells including CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML BC. CD135, also known as FMS-like tyrosine kinase 3, FLT3, STK1, and Flk2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc. In humans, expression of Flt3 is restricted to subsets of CD34 positive as well as CD34 negative normal bone marrow cells. In these cells, the level of expression of Flt3 is rather low. Most of the CD34 bright Flt3+ cells co-express CD117 at high levels. They may represent early cycling, but not quiescent stem cells. Flt3+ cells in the CD34lo and CD34- populations do not co-express CD117 molecule and may represent B lymphoid precursors.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human FLT3 around the phosphorylation site of Tyr599
抗原种属
Human
基因名称
FLT3
基因ID
2322
蛋白名称
Receptor-type tyrosine-protein kinase FLT3
Uniprot ID
P36888
功能
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
化学信息
分子量Theoretical: 109 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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