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顶部生物活性储存和溶解信息计算器

Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody

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产品编号 TMAB-10700

Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-FGFR1 (Tyr653+Tyr654)。Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody

Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10700

Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-FGFR1 (Tyr653+Tyr654)。Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FGFR1 (Tyr653+Tyr654). Anti-Phospho-FGFR1 (Tyr653+Tyr654) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Rabbit)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle.
组织特异性Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human FGFR1 around the phosphorylation site of Tyr653/654
抗原种属
Human
基因名称
FGFR1
基因ID
2260
蛋白名称
Fibroblast growth factor receptor 1
Uniprot ID
P11362
功能
Receptor for fibroblast growth factors FGF2 and FGF1. Receptor for FGF23 in the presence of KL (By similarity). Promotes mitogenesis in response to fibroblast growth factors. Activates PLCG1.
化学信息
分子量Theoretical: 88 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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