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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody

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货号 TMAB-10663

Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ERBB3 (Tyr1289)。Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody

Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10663

Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ERBB3 (Tyr1289)。Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ERBB3 (Tyr1289). Anti-Phospho-ERBB3 (Tyr1289) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Cell membrane; Single-pass type I. membrane protein. Isoform 2: Secreted.
组织特异性Epithelial tissues and brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human HER3 around the phosphorylation site of Tyr1289
抗原种属
Human
基因名称
ERBB3
基因ID
2065
蛋白名称
Receptor tyrosine-protein kinase erbB-3
Uniprot ID
P21860
功能
Binds and is activated by neuregulins and NTAK.
化学信息
分子量Theoretical: 148 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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